General Lee

What factors played into General Lee's defeat at Gettysburg?

It would SEEM that Lee had several disagreements with other generals concerning the placement of Confederate troops. I thought Lee was supposed to be a highly skilled General, so I was thinking maybe it was the intervention of other Generals that skewed his plans?
(ANY info on Gettysburg is much appreciated! Will award best answer!)

From Shmoop History/Battle of Gettysburg/General Lee

The ensuing Battle of Gettysburg, however, turned into a disaster when Lee ordered a huge frontal assault at the middle of the northern line, a doomed attack known to history as Pickett's Charge. The South never recovered from the losses of that day, and Lee spent the remainder of the war doing his best to hold off the inevitable. His surrender after the nine-month siege of Petersburg ended all major southern resistance. Lee is still remembered as a great hero of the southern cause.

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